AMYLOIDOSIS : CAUSES , SYMPTOMS, RISK FACTORS

 AMYLOIDOSIS 

Amyloidosis is a rare disease that occurs when a protein  called  amyloid builds up in organs . This amyloid can make the organs not work properly . Organs  that may be affected  include the heart , kindey , liver , spleen , nervous system and digestive tract . 



Some types of amyloidosi occur with strong drugs used to treat cancer . other of medications can reduce amyloid production and control symptoms . Some people may benefits from organ or stem cell transplants. 

SYMPTOMS OF AMYLOIDOSIS



Symptoms until later in the course of the disease . Symptoms may vary, depending on which organs are affected .
Signs and Symptoms of amyloidosis may include:
- Severe fatigue and weakness
- Shortness of breath 
- Numbness , tingling , or pain in the hands or feet 
- Swelling of the ankles and legs 
- Diarrhea , possibly with blood , or constipation 
- An enlarged tongue , which sometimes looks rippled around its edge 
- Skin changes , such as thickening or easy bruishing , and purplish patches around the eyes 


CAUSES OF AMYLOIDOSIS 

There are many differnt types of amyloidosis . Some types are hereditary . Others are caused  by outside factors , such as inflammatory diseases or long - term dialysis . Many types affect multiple organs . others affect only one part of the part of the body . 

TYPES OF AMYLOIDOSIS :




1. AL AMYLOIDOSIS : This is teh most common type of amyloidosis in developed countries. It is also called amyloidosis . It usually effects the kidneys, liver & nerves . 

2. AA  AMYLOIDOSIS : This type is also known as secondary amylodosis . Its usually triggered by an inflammatory disease, such as rheumatoid arthritis.

3. HEREDITARY AMYLOIDOSIS : This inherited disorder often affects the nerves , heart and kidneys . It most commonly happens when a protein made by your liver is abnormal . 

4. WILD TYPE AMYLOIDOSIS : This variety has also been called senile systemic amyloidosis . It occurs when the TTR protein made by the liver is normal but produces amyloid for unknown reasons . 

5. LOCALIZED AMYLOIDOSIS : This tyoe od amyloidosis often has a better prognosis than the varieties that affects multiple organ systems . Correct diagnosis is important so that treatments that affect the entire body can be avoided . 

RISK FACTORS 



Factors that increase the risk of amyloidosis include :

1. age most people diagonsed with amyloidosis are between age - 60 to 70.
2. sex amyloidosis occurs more commonly in men . 
3. other diseases having a chronic infectious of inflammatory disease increases the risk of AA amyloidosis.
4. family history  some types od amyloidosis are hereditary . 
5. kidney dialysis  can't always remove large proteins from from the blood . Abnormal proteins can build up in your  blood and eventually be deposited in tissues . 
6. Race - people os African descent appear to be at higher risk of carrying a genetics mutation associated  with a type of amyloidosis that can harm the heart . 

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