Is erythromelalgia autoimmune disease ?

 ERYTHROMELALGIA

Erythromelalgia is a rare disorder that can affect your feet, hands and other areas . Symptoms may come and go . They include  skin redness and an intense burning sensation . This can make sleeping , walking  and other  tasks challenging . Medications  may help symptoms flares . 


Erythromelalgia is a rare condition in which excess blood flow causes periodic symptoms  flares. Its a chronic condition , meaning that it stay with you for life. Erythromelalgia symptoms , which often  include burning pain, worsen over time . 

Erythromelalgia  typically affects your feet but can  also occur on your :

- ARMS

- FACE

- HANDS 

- LEGS

Pictures of erythromelalagia:




Different types of erythromelalgia:

Primary  erythromelalgia is isolated and not due to an underlying disease.

-Idiopathic erythromelalgia : is  the most common type and  occurs for unkown reasons . 

-Inherited erythromelalgia  : is due to gene mutations. The mutations , which affect  pain signals, can be passed down  in families . 

Secondary erythromelalgia occurs when there is an  underlying blood , neurological or  immunologic conditions  these include :
Autoimmune disease , such as lupus and multiple your body to produce too many platelets .
Polycthemia vera 
Raynaud's phenomena 
Thrombocytopenia 
Neuropathy 

What are erythromelalgia symptoms ?





The Three primary erythromelalgia symptoms are :
1. increase in skin temperature 
2. Pain that ranges from mild tingling to severe burning 
3. skin redness. 

Symptoms may also include :
  • Itching 
  • skin that's cold to the touch betwwen flares 
  • sweating in an area more than you usually would 
  • swelling 
  • tender, blotchy skin 
  • tingling sensation 

Symptoms may occur on one or both sides of your body. they can range from mild to intense,  of some people experience their first flare in childhood , while other aren't affected until adulthood . 

What are the causes of erythromelalgia symptoms flares ?

Flares usually occur when you experience a sudden increase in body temperature . This may happen when you are :
1. Consuming caffeinated beverages 
2. Dehydrated 
3. Drinking alcohol
4. eating spicy food 
5. exercising 
6. feeling stressed 
7. In a warm room or environment 

How to treat erythromelalgia disease ?


Secondary erythromelalgia , treatment of the underlying primary disorder is the most  primary  method of treatment . It is rare to find evidence that this is effective . Mechanical cooling of the limbs by elevating them can help or managing the ambient enviroment  frequently is often necessary  constantly as flares occur due to sympathetic autonomic  dysfunction of the capillaries. The pain that accompanies it is severe and treated separately . It precipitates problems further  down the line causing  damage to the skin and ulceration often interactable  due to the damaged skin. a possible reduction in skin damage may be accomplished by enclosing the flaring limb in a cold water to relieve symptoms when flaring  occurs .

primary erythromamelalagia  management is symptomatic, i.e. treating painful symptoms only. specific management tactics include avoidance of attack triggers such as heat . changein temperature, exercises or over extertion , alcohol and spicy foods. In pursuit od added relief suffered can inadvertently cause tissue damage or death, ie necrosis. 

One clinically demonstrated  the efficacy of IV lidocanie or oral mesilitine , though  differences  betwwen  the primary and secondary  forms  were not studied . another  trial has shown promise  for misoprosal , while other have shown that  gabapentin  , venlafaxine and oral magnesium may also superseded this combination. 

Patients find relief by cooling the skin . All patients must be notify  to  not apply ice directly on to skin, since this can cause maceration  of the skin, nonhealing ulcers , infection , necrosis and even in severe cases. 
Mild suffererd may fiind sufficient pain relief with tramadol or amitriptyline . suffers of more  severe and widespread EM symptoms , however , may obtain relief only from opioid  drugs . 

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