SCLERODERMA : causes , symptoms , treatments

 SCLERODERMA 

Scleroderma is a chronic but rare autoimmune disease in which normal tissue is replaced with thick tissue with extra collagen . Although it most often affects the skin, scleroderma also can affect many other parts of the body . 



Scleroderma is a chronic , the immune system helps defend the body against disease and infection . In patients with scleroderma , the immune system  triggers other cells to produce too much collagen [ protein ] . The extra collagen is deposited in the skin & organ , which cause hardening and thickening . It most often affects the skin, scleroderma  also can affect many parts of the body including the gastrointestinal tract, lungs , kidney , heart , blood vessels , muscles and joints . Scleroderma in its most severe forms can be life - threatening . 

FORMS OF SCLERODERMA 

There are 2 major forms of scleroderma , localized  and systemic . Systemic scleroderma can be broken down into two main types : diffuse and limited .

Localized Scleroderma - The more common form of the disease , localized scleroderma , affects only a person's , usually in just a few places . Appears in the form of waxy patches or streaks on the skin .

Diffuse Scleroderma - This form affects many parts of the body . it affect the skin , but it also can affect many internal organs , Systemic scleroderma can sometimes become serious and life - threatening. 

Limited Scleroderma - Patients with limited scleroderma do not experience kidney problems . The skin thickening is restricted to the fingers , hands and forearms , and also sometimes the feet and legs . CREST syndrome, each letter stands for a features of the disease :

C  cinosis [ abnormal calcium deposits in the skin ]

R  aynaud's phenomena [ see the symptoms sections ]

sophageal dysmotility [ difficulty swallowing ]

S  clerodactyly al[ skin tightening on the fingers ] 

T  elangectasias [ red spots on the skin ] 


CAUSES OF SCLERODERMA 

The cause of scleroderma is unknown . Although rarely, scleroderma can run in families. most cases do not show in any family history of the disease . 



SYMPTOMS OF SCLERODERMA 

The thickening of skin, in the following other symptoms may occur in a person with scleroderma :

  • swelling of the hands and feet 
  • red spots on the skin 
  • excessive calcium deposition in the skin 
  • joint contractures 
  • tight mask like facial skin 
  • pain and stifffness in the joints 
  • shortness of breath 
  • heartburn 
  • constipation 
  • weightloss 
  • fatigue 

RISK FACTORS OF SCLERODERMA 




It usually happens in women and in peoplen who are age 35 - 55 . other things that might raise your risk include :

- certain changes in your genes 
- a family history of autoimmune disease 
-trigger in the world around you likr viruses , medications , or chemicals 

COMPLICATIONS OF SCLERODERMA 


Treatments can help lower your risk of complication , which may include :

- high blood pressure in your lungs 
- scar tissues in your lungs 
- loss of blood flow to your fingers and toes 
- muscles inflammation 
- infection 
- kidney failure 

TREATMENTS OF SCLERODERMA 


- steroids and other medication to slow your immune system , these can help with swelling and pain . 
- drugs to boost blood flow to your fingers 
- blood pressure medication 
- drugs to open blood vessels in your lungs or to keep tissue from scarring 
- heartburn medication 
- antibiotics 
- medications to help move food through you intestines . 
- exercise 
- physical therapy 
- occupational therapy
- stress management 
- organ transplant if organ are severely damaged 

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SYPHILIS : CAUSES , PREVENTION , RISK FACTORS